Long criticized as discriminatory, the policy has prevented many gay and bisexual men from donating blood. The Food and Drug Administration revealed a draft of its new approach on Friday.
Donors through The Red Cross typically give a pint of blood which can then be broken down into its individual components -- platelets, plasma and red blood cells.
The COVID-19 pandemic has contributed to a 62% drop in blood drives at schools and colleges, according to the American Red Cross.
The shift in health policy in most of the U.K. reverses a decades-old rule that limited donor eligibility on perceived risks of contracting HIV/AIDs and other sexually transmitted infections.
"Donors will no longer be asked to declare if they have had sex with another man, making the criteria for blood donation gender neutral and more inclusive," the National Health Service explains.