Many blame the agency's earlier guidance for suffering and even suicide risk among chronic pain patients. Critics say the updated advice may not fix the problem.

Companies at the center of the deadly prescription opioid epidemic are close to deals that would cap their liability while funding drug treatment and recovery programs.

The country's biggest name-brand pharmacy chains face a high-profile civil trial beginning Monday in Cleveland, Ohio over their role in the nation's deadly opioid epidemic.

Cherokee Nation officials say their community has been disproportionately harmed by the opioid crisis. The drug companies deny any wrongdoing.

People who were addicted to OxyContin or lost loved ones who were addicted to the drug expect very little in compensation from the multibillion-dollar Purdue Pharma bankruptcy settlement.

Newly published U.S. data finds overdose deaths from methamphetamine use more than doubled in recent years. Use of the stimulant among Black Americans surged nearly tenfold.

The DOJ is seeking to block implementation of any part of the Purdue Pharma bankruptcy deal until legal challenges are settled. The deal granted Sackler family members immunity from opioid lawsuits.

The decision by a federal bankruptcy judge grants members of the family who own Purdue Pharma, maker of OxyContin, sweeping protection from any liability for the opioid crisis.

A bankruptcy judge cleared a plan for final vote by creditors of Purdue Pharma, maker of OxyContin, that would release the Sacklers and their financial empire from liability for the opioid crisis.

Attorneys, forensic analysts and other financial experts working for Purdue Pharma spent nearly two years looking for evidence of wrongdoing by the Sacklers. Critics want the findings made public.

The giant retailer shipped billions of opioid pills to pharmacies nationwide. An NPR investigation found employees warned company executives their stores were being used by "pill mill" doctors.

The Justice Department says the retailer ignored red flags for years, filling suspicious prescriptions for opioids and contributing to America's deadly addiction crisis. Walmart denies wrongdoing.

China banned fentanyl last year, but an NPR investigation reveals how Chinese vendors continue to market the chemicals used to make the drug on e-commerce and social media sites.

President Trump promised to end America's opioid crisis. On his watch overdose deaths flattened in 2018 then surged again to record levels.

On this edition of Political Rewind, the opioid crisis is a nationwide plague, killing or holding hostage to drug addiction countless Americans.