Sweeping cuts to mental health and addiction programs worth more than $2 billion are being reversed. After a political backlash from Republicans and Democrats, the grant money will be restored.

The experiences of one doctor in Louisiana reveal the tensions around trying to get people to engage in addiction treatment, even if they're not ready to stop using drugs.

A federal bankruptcy court judge said he will approve OxyContin-maker Purdue Pharma's latest deal to settle thousands of lawsuits over the toll of opioids that includes some money for thousands of victims of the epidemic.

The latest 12-month report from the CDC showed 1,400 more deaths in January of this year compared with the year prior. This comes after more than a year of dramatic progress. Experts say they're not sure if this is a "blip" or something more troubling.

A new $7.4 billion opioid settlement for Purdue Pharma and the Sackler family has been approved by all U.S. states and territories

An effective treatment for opioid addiction is easier to get after the Biden administration changed rules. That's making a difference for some people battling opioid use disorder, but access is still limited.

For decades, tianeptine was used to treat depression, even though no one knew how it worked. But it turns out it's a type of opioid, and the U.S. is facing a spike in abuse of "gas station heroin."

A new study finds a 50-fold growth in deaths from combined use of stimulants and opioids. The toxic and contaminated drug supply is to blame.

New research calls into question prescribing the drugs even for short-term pain relief – especially given the risk of addiction.

Republican lawmakers want Mexico to accept U.S. military aid to cripple drug cartels making and smuggling deadly fentanyl. López Obrador mocked the idea as a threat to his country's sovereignty.

Federal prosecutors in Southeast Georgia announced Wednesday a massive drug trafficking indictment, charging 76 people — including a state prison guard — with operating a drug distribution network of opioids and other controlled substances in and around Brunswick's Glynn County.

The retail giant becomes the latest major player in the drug industry to announce a plan to settle lawsuits filed by state and local governments over the toll of opioids sold at its pharmacies.

The updated recommendations seek to course correct after guidelines from 2016 were criticized for harshly limiting access to needed pain medication.

Many blame the agency's earlier guidance for suffering and even suicide risk among chronic pain patients. Critics say the updated advice may not fix the problem.

Companies at the center of the deadly prescription opioid epidemic are close to deals that would cap their liability while funding drug treatment and recovery programs.