Coco Gauff will face No. 10 Karolina Muchova of the Czech Republic on Thursday. The unseeded Ben Shelton will next meet 23-time major champion Novak Djokovic of Serbia.
Several of the players marked firsts for the sport's history, while for Serena Williams, the tournament may have been her last match.
No. 22 seed Frances Tiafoe defeats Rafael Nadal to end the Spaniard's 22-match Grand Slam winning streak and reach the U.S. Open quarterfinals for the first time.
Serena Williams eliminated No. 2 seed Anett Kontaveit at the U.S. Open to ensure that she will play at least one more singles match at what she's hinted will be the last tournament of her career.
The No. 2 men's tennis player will not be allowed to enter the United States because he remains unvaccinated against COVID-19.
The prime ministers of Australia and Serbia talked by phone about the tennis star's visa as he is seeded No. 1 in Australian Open.
Ending her most recent quest to tie the record for the most Grand Slam singles titles, Serena Williams had to pull out due to a flare-up from a previous injury.