More than 5,000 barrels of depleted uranium are making their way by train from the Savannah River Site near Augusta to a disposal facility in Clive, Utah.
This despite protests from Utah Governor Gary Herbert.
In a letter to Energy Secretary Steven Chu earlier this week, Herbert asked the delivery be delayed while his state considers stricter guidelines for nuclear waste disposal.
Officials with the Department of Energy say the letter came too late to stop the shipment.
Frank Marcinowski is a spokesman for the DOE.
"We have been in regular communication with the regulators in Utah as well as the Nuclear Regulatory Commission and we are in compliance with all of the regulatory requirements and, as of now, the shipments are proceeding as planned," he said.
The DOE plans to move a total of 15,000 barrels of waste from SRS to the Utah facility by the Spring of next year.